Transcriptomic analysis brings new insight into the biological role of the prion protein during mouse embryogenesis.
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ABSTRACT:
SUBMITTER: Khalife M
PROVIDER: S-EPMC3156130 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
Transcriptomic analysis brings new insight into the biological role of the prion protein during mouse embryogenesis.
Khalifé Manal M Young Rachel R Passet Bruno B Halliez Sophie S Vilotte Marthe M Jaffrezic Florence F Marthey Sylvain S Béringue Vincent V Vaiman Daniel D Le Provost Fabienne F Laude Hubert H Vilotte Jean-Luc JL
PloS one 20110815 8
The biological function of the Prion protein remains largely unknown but recent data revealed its implication in early zebrafish and mammalian embryogenesis. To gain further insight into its biological function, comparative transcriptomic analysis between FVB/N and FVB/N Prnp knockout mice was performed at early embryonic stages. RNAseq analysis revealed the differential expression of 73 and 263 genes at E6.5 and E7.5, respectively. The related metabolic pathways identified in this analysis part ...[more]
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