Ontology highlight
ABSTRACT:
SUBMITTER: Whitman CM
PROVIDER: S-EPMC3156312 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20110506 17
Metabolic oligosaccharide engineering is powerful approach to altering the structure of cellular sialosides. This method relies on culturing cells with N-acetylmannosamine (ManNAc) analogs that are metabolized to their sialic acid counterparts and added to glycoproteins and glycolipids. Here we employed two cell lines that are deficient in ManNAc biosynthesis and examined their relative abilities to metabolize a panel of ManNAc analogs to sialosides. In addition to measuring global sialoside pro ...[more]