Ontology highlight
ABSTRACT:
SUBMITTER: Woodward JJ
PROVIDER: S-EPMC3156580 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Woodward Joshua J JJ Iavarone Anthony T AT Portnoy Daniel A DA
Science (New York, N.Y.) 20100527 5986
Intracellular bacterial pathogens, such as Listeria monocytogenes, are detected in the cytosol of host immune cells. Induction of this host response is often dependent on microbial secretion systems and, in L. monocytogenes, is dependent on multidrug efflux pumps (MDRs). Using L. monocytogenes mutants that overexpressed MDRs, we identified cyclic diadenosine monophosphate (c-di-AMP) as a secreted molecule able to trigger the cytosolic host response. Overexpression of the di-adenylate cyclase, da ...[more]