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Dehydroepiandrosterone (DHEA) replacement decreases insulin resistance and lowers inflammatory cytokines in aging humans.

ABSTRACT: Plasma dehydroepiandrosterone (DHEA) decreases ~80% between ages 25 and 75 yr. In a preliminary study, we found that 6 mo of DHEA replacement improved insulin action in elderly individuals. The purpose of the present larger, randomized double-blind study was to determine whether a longer period of DHEA replacement improves glucose tolerance. Fifty-seven men and 68 women aged 65 to 75 yr were randomly assigned to 50 mg DHEA or placebo once daily. Year one was a randomized, double blind trial. Year 2 was an open label continuation. DHEA replacement improved glucose tolerance in participants who had abnormal GT initially, reduced plasma triglycerides, and the inflammatory cytokines IL6 and TNF?.

SUBMITTER: Weiss EP

PROVIDER: S-EPMC3156603 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature

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Dehydroepiandrosterone (DHEA) replacement decreases insulin resistance and lowers inflammatory cytokines in aging humans.

Weiss Edward P EP Villareal Dennis T DT Fontana Luigi L Han Dong-Ho DH Holloszy John O JO

Aging 20110501 5

Plasma dehydroepiandrosterone (DHEA) decreases ~80% between ages 25 and 75 yr. In a preliminary study, we found that 6 mo of DHEA replacement improved insulin action in elderly individuals. The purpose of the present larger, randomized double-blind study was to determine whether a longer period of DHEA replacement improves glucose tolerance. Fifty-seven men and 68 women aged 65 to 75 yr were randomly assigned to 50 mg DHEA or placebo once daily. Year one was a randomized, double blind trial. Yea ...[more]

PMID: 21566261

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| S-EPMC11021003 | biostudies-literature

COVID-19 convalescent plasma therapy decreases inflammatory cytokines: a randomized controlled trial.

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| S-EPMC10783116 | biostudies-literature

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