Ontology highlight
ABSTRACT:
SUBMITTER: Al-Bassam J
PROVIDER: S-EPMC3156696 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Al-Bassam Jawdat J Kim Hwajin H Brouhard Gary G van Oijen Antoine A Harrison Stephen C SC Chang Fred F
Developmental cell 20100801 2
Spatial regulation of microtubule (MT) dynamics contributes to cell polarity and cell division. MT rescue, in which a MT stops shrinking and reinitiates growth, is the least understood aspect of MT dynamics. Cytoplasmic Linker Associated Proteins (CLASPs) are a conserved class of MT-associated proteins that contribute to MT stabilization and rescue in vivo. We show here that the Schizosaccharomyces pombe CLASP, Cls1p, is a homodimer that binds an alphabeta-tubulin heterodimer through conserved T ...[more]