Ontology highlight
ABSTRACT:
SUBMITTER: Lu CW
PROVIDER: S-EPMC3157210 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Lu Chun-Wun CW Lin Shau-Chieh SC Chien Chun-Wei CW Lin Shih-Chieh SC Lee Chung-Ta CT Lin Bo-Wen BW Lee Jenq-Chang JC Tsai Shaw-Jenq SJ
The American journal of pathology 20110718 3
The switch of cellular metabolism from mitochondrial respiration to glycolysis is the hallmark of cancer cells and is associated with tumor malignancy. Pyruvate dehydrogenase kinase-1 (PDK1) and PDK3 participate in the metabolic switch of cancer cells; however, the medical significance of PDK1 and PDK3 in cancer progression is not known. Here, we assessed the expression profiles of PDK1 and PDK3 in colorectal cancer. Western blot analysis (n = 74) demonstrated that PDK3 was markedly increased in ...[more]