Resident B cells regulate thymic expression of myelin oligodendrocyte glycoprotein.
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ABSTRACT:
SUBMITTER: Akirav EM
PROVIDER: S-EPMC3157307 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Publications
Resident B cells regulate thymic expression of myelin oligodendrocyte glycoprotein.
Akirav Eitan M EM Xu Yan Y Ruddle Nancy H NH
Journal of neuroimmunology 20110507 1-2
Thymic B cells represent a numerically minor cell population located primarily at the cortico-medullary junction. Their biological role is unclear. B cell-deficient μMT mice exhibited reduced medullary thymic epithelial cell (mTEC) numbers and reduced MOG and insulin mRNA expression. Lymphotoxin produced by B cells was critical for normal tissue restricted antigen (TRA) expression, suggesting that B cells regulate self-antigens through their production of LT. These results reveal an unexpected r ...[more]
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