Ontology highlight
ABSTRACT:
SUBMITTER: Finley LW
PROVIDER: S-EPMC3157345 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Finley Lydia W S LW Haas Wilhelm W Desquiret-Dumas Valérie V Wallace Douglas C DC Procaccio Vincent V Gygi Steven P SP Haigis Marcia C MC
PloS one 20110817 8
<h4>Background</h4>Sirtuins (SIRT1-7) are a family of NAD-dependent deacetylases and/or ADP-ribosyltransferases that are involved in metabolism, stress responses and longevity. SIRT3 is localized to mitochondria, where it deacetylates and activates a number of enzymes involved in fuel oxidation and energy production.<h4>Methodology/principal findings</h4>In this study, we performed a proteomic screen to identify SIRT3 interacting proteins and identified several subunits of complex II and V of th ...[more]