Ontology highlight
ABSTRACT:
SUBMITTER: Lee FY
PROVIDER: S-EPMC3157481 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Lee Florence Y FY Faivre Emily J EJ Suzawa Miyuki M Lontok Erik E Ebert Daniel D Cai Fang F Belsham Denise D DD Ingraham Holly A HA
Developmental cell 20110804 2
Sumoylation is generally considered a repressive mark for many transcription factors. However, the in vivo importance of sumoylation for any given substrate remains unclear and is questionable because the extent of sumoylation appears exceedingly low for most substrates. Here, we permanently eliminated SF-1/NR5A1 sumoylation in mice (Sf-1(K119R, K194R, or 2KR)) and found that Sf-1(2KR/2KR) mice failed to phenocopy a simple gain of SF-1 function or show elevated levels of well-established SF-1 ta ...[more]