Ontology highlight
ABSTRACT:
SUBMITTER: Kallenberg CG
PROVIDER: S-EPMC3157640 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Kallenberg Cees G M CG Vissink Arjan A Kroese Frans G M FG Abdulahad Wayel H WH Bootsma Hendrika H
Arthritis research & therapy 20110228 1
In vitro and in vivo experimental data have pointed to new immunopathogenic mechanisms in primary Sjögren's syndrome (pSS). The availability of targeted treatment modalities has opened new ways to selectively target these mechanistic pathways in vivo. This has taught us that the role of proinflammatory cytokines, in particular TNFα, is not crucial in the immunopathogenesis of pSS. B cells appear to play a major role, as depletion of B cells leads to restoration of salivary flow and is efficaciou ...[more]