Ontology highlight
ABSTRACT:
SUBMITTER: Padrick SB
PROVIDER: S-EPMC3158169 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Padrick Shae B SB Doolittle Lynda K LK Brautigam Chad A CA King David S DS Rosen Michael K MK
Proceedings of the National Academy of Sciences of the United States of America 20110615 33
Actin related protein 2/actin related protein 3 (Arp2/3) complex nucleates new actin filaments in eukaryotic cells in response to signals from proteins in the Wiskott-Aldrich syndrome protein (WASP) family. The conserved VCA domain of WASP proteins activates Arp2/3 complex by inducing conformational changes and delivering the first actin monomer of the daughter filament. Previous models of activation have invoked a single VCA acting at a single site on Arp2/3 complex. Here we show that activatio ...[more]