Ontology highlight
ABSTRACT:
SUBMITTER: Lin W
PROVIDER: S-EPMC3158206 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Lin Wenchu W Cao Jian J Liu Jiayun J Beshiri Michael L ML Fujiwara Yuko Y Francis Joshua J Cherniack Andrew D AD Geisen Christoph C Blair Lauren P LP Zou Mike R MR Shen Xiaohua X Kawamori Dan D Liu Zongzhi Z Grisanzio Chiara C Watanabe Hideo H Minamishima Yoji Andrew YA Zhang Qing Q Kulkarni Rohit N RN Signoretti Sabina S Rodig Scott J SJ Bronson Roderick T RT Orkin Stuart H SH Tuck David P DP Benevolenskaya Elizaveta V EV Meyerson Matthew M Kaelin William G WG Yan Qin Q
Proceedings of the National Academy of Sciences of the United States of America 20110725 33
Aberrations in epigenetic processes, such as histone methylation, can cause cancer. Retinoblastoma binding protein 2 (RBP2; also called JARID1A or KDM5A) can demethylate tri- and dimethylated lysine 4 in histone H3, which are epigenetic marks for transcriptionally active chromatin, whereas the multiple endocrine neoplasia type 1 (MEN1) tumor suppressor promotes H3K4 methylation. Previous studies suggested that inhibition of RBP2 contributed to tumor suppression by the retinoblastoma protein (pRB ...[more]