Role for the actomyosin complex in regulated exocytosis revealed by intravital microscopy.
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ABSTRACT:
SUBMITTER: Masedunskas A
PROVIDER: S-EPMC3158220 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Publications
Role for the actomyosin complex in regulated exocytosis revealed by intravital microscopy.
Masedunskas Andrius A Sramkova Monika M Parente Laura L Sales Katiuchia Uzzun KU Amornphimoltham Panomwat P Bugge Thomas H TH Weigert Roberto R
Proceedings of the National Academy of Sciences of the United States of America 20110801 33
The regulation and the dynamics of membrane trafficking events have been studied primarily in in vitro models that often do not fully reflect the functional complexity found in a living multicellular organism. Here we used intravital microscopy in the salivary glands of live rodents to investigate regulated exocytosis, a fundamental process in all of the secretory organs. We found that β-adrenergic stimulation elicits exocytosis of large secretory granules, which gradually collapse with the apic ...[more]
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