New covalent capture probes for imaging and therapy, based on a combination of binding affinity and disulfide bond formation.
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ABSTRACT:
SUBMITTER: Aweda TA
PROVIDER: S-EPMC3158659 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Publications
New covalent capture probes for imaging and therapy, based on a combination of binding affinity and disulfide bond formation.
Aweda Tolulope A TA Eskandari Vahid V Kukis David L DL Boucher David L DL Marquez Bernadette V BV Beck Heather E HE Mitchell Gregory S GS Cherry Simon R SR Meares Claude F CF
Bioconjugate chemistry 20110722 8
We describe the synthesis and development of new reactive DOTA-metal complexes for covalently targeting engineered receptors in vivo, which have superior tumor uptake and clearance properties for biomedical applications. These probes are found to clear efficiently through the kidneys and minimally through other routes, but bind persistently in the tumor target. We also explore the new technique of Cerenkov luminescence imaging to optically monitor radiolabeled probe distribution and kinetics in ...[more]
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