Ontology highlight
ABSTRACT:
SUBMITTER: Lakshmikanthan S
PROVIDER: S-EPMC3158727 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Lakshmikanthan Sribalaji S Sobczak Magdalena M Chun Changzoon C Henschel Angela A Dargatz Jillian J Ramchandran Ramani R Chrzanowska-Wodnicka Magdalena M
Blood 20110602 7
Vascular endothelial growth factor (VEGF) acting through VEGF receptor 2 (VEGFR2) on endothelial cells (ECs) is a key regulator of angiogenesis, a process essential for wound healing and tumor metastasis. Rap1a and Rap1b, 2 highly homologous small G proteins, are both required for angiogenesis in vivo and for normal EC responses to VEGF. Here we sought to determine the mechanism through which Rap1 promotes VEGF-mediated angiogenesis. Using lineage-restricted Rap1-knockout mice we show that Rap1- ...[more]