Dissecting protein loops with a statistical scalpel suggests a functional implication of some structural motifs.
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ABSTRACT:
SUBMITTER: Regad L
PROVIDER: S-EPMC3158783 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
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Dissecting protein loops with a statistical scalpel suggests a functional implication of some structural motifs.
Regad Leslie L Martin Juliette J Camproux Anne-Claude AC
BMC bioinformatics 20110620
<h4>Background</h4>One of the strategies for protein function annotation is to search particular structural motifs that are known to be shared by proteins with a given function.<h4>Results</h4>Here, we present a systematic extraction of structural motifs of seven residues from protein loops and we explore their correspondence with functional sites. Our approach is based on the structural alphabet HMM-SA (Hidden Markov Model - Structural Alphabet), which allows simplification of protein structure ...[more]
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