Ontology highlight
ABSTRACT:
SUBMITTER: Harada M
PROVIDER: S-EPMC3159073 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Harada Michishige M Hirota Tomomitsu T Jodo Aya I AI Hitomi Yuki Y Sakashita Masafumi M Tsunoda Tatsuhiko T Miyagawa Takehiko T Doi Satoru S Kameda Makoto M Fujita Kimie K Miyatake Akihiko A Enomoto Tadao T Noguchi Emiko E Masuko Hironori H Sakamoto Tohru T Hizawa Nobuyuki N Suzuki Yoichi Y Yoshihara Shigemi S Adachi Mitsuru M Ebisawa Motohiro M Saito Hirohisa H Matsumoto Kenji K Nakajima Toshiharu T Mathias Rasika A RA Rafaels Nicholas N Barnes Kathleen C KC Himes Blanca E BE Duan Qing Ling QL Tantisira Kelan G KG Weiss Scott T ST Nakamura Yusuke Y Ziegler Steven F SF Tamari Mayumi M
American journal of respiratory cell and molecular biology 20100723 6
Thymic stromal lymphopoietin (TSLP) triggers dendritic cell--mediated T helper (Th) 2 inflammatory responses. A single-nucleotide polymorphism (SNP), rs3806933, in the promoter region of the TSLP gene creates a binding site for the transcription factor activating protein (AP)-1. The variant enhances AP-1 binding to the regulatory element, and increases the promoter--reporter activity of TSLP in response to polyinosinic-polycytidylic acid (poly[I:C]) stimulation in normal human bronchial epitheli ...[more]