Ontology highlight
ABSTRACT:
SUBMITTER: Tong X
PROVIDER: S-EPMC3159441 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Tong Xiaotian X Lan Wenxian W Zhang Xu X Wu Houming H Liu Maili M Cao Chunyang C
Nucleic acids research 20110502 15
RET protein functions as a receptor-type tyrosine kinase and has been found to be aberrantly expressed in a wide range of human diseases. A highly GC-rich region upstream of the promoter plays an important role in the transcriptional regulation of RET. Here, we report the NMR solution structure of the major intramolecular G-quadruplex formed on the G-rich strand of this region in K(+) solution. The overall G-quadruplex is composed of three stacked G-tetrad and four syn guanines, which shows dist ...[more]