Ontology highlight
ABSTRACT:
SUBMITTER: Sela M
PROVIDER: S-EPMC3160187 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Sela Meirav M Bogin Yaron Y Beach Dvora D Oellerich Thomas T Lehne Johanna J Smith-Garvin Jennifer E JE Okumura Mariko M Starosvetsky Elina E Kosoff Rachelle R Libman Evgeny E Koretzky Gary G Kambayashi Taku T Urlaub Henning H Wienands Jürgen J Chernoff Jonathan J Yablonski Deborah D
The EMBO journal 20110701 15
Cooperatively assembled signalling complexes, nucleated by adaptor proteins, integrate information from surface receptors to determine cellular outcomes. In T and mast cells, antigen receptor signalling is nucleated by three adaptors: SLP-76, Gads and LAT. Three well-characterized SLP-76 tyrosine phosphorylation sites recruit key components, including a Tec-family tyrosine kinase, Itk. We identified a fourth, evolutionarily conserved SLP-76 phosphorylation site, Y173, which was phosphorylated up ...[more]