Ontology highlight
ABSTRACT:
SUBMITTER: Sun F
PROVIDER: S-EPMC3160654 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Sun Faneng F Zhu Chuanmei C Dixit Ram R Cavalli Valeria V
The EMBO journal 20110712 16
Neuronal development, function and repair critically depend on axonal transport of vesicles and protein complexes, which is mediated in part by the molecular motor kinesin-1. Adaptor proteins recruit kinesin-1 to vesicles via direct association with kinesin heavy chain (KHC), the force-generating component, or via the accessory light chain (KLC). Binding of adaptors to the motor is believed to engage the motor for microtubule-based transport. We report that the adaptor protein Sunday Driver (syd ...[more]