Ontology highlight
ABSTRACT:
SUBMITTER: Persaud A
PROVIDER: S-EPMC3160656 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Persaud Avinash A Alberts Philipp P Hayes Madeline M Guettler Sebastian S Clarke Ian I Sicheri Frank F Dirks Peter P Ciruna Brian B Rotin Daniela D
The EMBO journal 20110715 16
Fibroblast growth factor receptor 1 (FGFR1) has critical roles in cellular proliferation and differentiation during animal development and adult homeostasis. Here, we show that human Nedd4 (Nedd4-1), an E3 ubiquitin ligase comprised of a C2 domain, 4 WW domains, and a Hect domain, regulates endocytosis and signalling of FGFR1. Nedd4-1 binds directly to and ubiquitylates activated FGFR1, by interacting primarily via its WW3 domain with a novel non-canonical sequence (non-PY motif) on FGFR1. Delet ...[more]