Ontology highlight
ABSTRACT:
SUBMITTER: Wang KS
PROVIDER: S-EPMC3160901 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Wang Ke-Sheng KS Chen Gang G Shen Hai-Lian HL Li Ting-Ting TT Chen Fei F Wang Qin-Wan QW Wang Zhi-Qin ZQ Han Ze-Guang ZG Zhang Xin X
PloS one 20110824 8
The tumor suppressor p53 controls multiple cellular functions including DNA repair, cell cycle arrest and apoptosis. MDM2-mediated p53 ubiquitination affects both degradation and cytoplasmic localization of p53. Several cofactors are known to modulate MDM2-mediated p53 ubiquitination and proteasomal degradation. Here we show that IRTKS, a novel IRSp53-like protein inhibited p53-induced apoptosis and depressed its transcription activity. IRTKS bound directly to p53 and increased p53 ubiquitinatio ...[more]