Ontology highlight
ABSTRACT:
SUBMITTER: Cherkasova E
PROVIDER: S-EPMC3161150 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Cherkasova E E Malinzak E E Rao S S Takahashi Y Y Senchenko V N VN Kudryavtseva A V AV Nickerson M L ML Merino M M Hong J A JA Schrump D S DS Srinivasan R R Linehan W M WM Tian X X Lerman M I MI Childs R W RW
Oncogene 20110523 47
A human endogenous retrovirus type E (HERV-E) was recently found to be selectively expressed in most renal cell carcinomas (RCCs). Importantly, antigens derived from this provirus are immunogenic, stimulating cytotoxic T cells that kill RCC cells in vitro and in vivo. Here, we show HERV-E expression is restricted to the clear cell subtype of RCC (ccRCC) characterized by an inactivation of the von Hippel-Lindau (VHL) tumor-suppressor gene with subsequent stabilization of hypoxia-inducible transcr ...[more]