Ontology highlight
ABSTRACT:
SUBMITTER: Miyanaga A
PROVIDER: S-EPMC3161154 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Miyanaga Akimasa A Janso Jeffrey E JE McDonald Leonard L He Min M Liu Hongbo H Barbieri Laurel L Eustáquio Alessandra S AS Fielding Elisha N EN Carter Guy T GT Jensen Paul R PR Feng Xidong X Leighton Margaret M Koehn Frank E FE Moore Bradley S BS
Journal of the American Chemical Society 20110809 34
The pyrroloquinoline alkaloid family of natural products, which includes the immunosuppressant lymphostin, has long been postulated to arise from tryptophan. We now report the molecular basis of lymphostin biosynthesis in three marine Salinispora species that maintain conserved biosynthetic gene clusters harboring a hybrid nonribosomal peptide synthetase-polyketide synthase that is central to lymphostin assembly. Through a series of experiments involving gene mutations, stable isotope profiling, ...[more]