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Influence of solubilizing environments on membrane protein structures.

ABSTRACT: Membrane protein structures are stabilized by weak interactions and are influenced by additional interactions with the solubilizing environment. Structures of influenza virus A M2 protein, a proven drug target, have been determined in three different environments, thus providing a unique opportunity to assess environmental influences. Structures determined in detergents and detergent micelles can have notable differences from those determined in lipid bilayers. These differences make it imperative to validate membrane protein structures.

SUBMITTER: Cross TA

PROVIDER: S-EPMC3161620 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature

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Influence of solubilizing environments on membrane protein structures.

Cross Timothy A TA Sharma Mukesh M Yi Myunggi M Zhou Huan-Xiang HX

Trends in biochemical sciences 20100818 2

Membrane protein structures are stabilized by weak interactions and are influenced by additional interactions with the solubilizing environment. Structures of influenza virus A M2 protein, a proven drug target, have been determined in three different environments, thus providing a unique opportunity to assess environmental influences. Structures determined in detergents and detergent micelles can have notable differences from those determined in lipid bilayers. These differences make it imperati ...[more]

PMID: 20724162

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