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Antipsychotic drugs and heart muscle disorder in international pharmacovigilance: data mining study.


ABSTRACT: OBJECTIVES:To examine the relation between antipsychotic drugs and myocarditis and cardiomyopathy. DESIGN:Data mining using bayesian statistics implemented in a neural network architecture. SETTING:International database on adverse drug reactions run by the World Health Organization programme for international drug monitoring. MAIN OUTCOME MEASURES:Reports mentioning antipsychotic drugs, cardiomyopathy, or myocarditis. RESULTS:A strong signal existed for an association between clozapine and cardiomyopathy and myocarditis. An association was also seen with other antipsychotics as a group. The association was based on sufficient cases with adequate documentation and apparent lack of confounding to constitute a signal. Associations between myocarditis or cardiomyopathy and lithium, chlorpromazine, fluphenazine, haloperidol, and risperidone need further investigation. CONCLUSIONS:Some antipsychotic drugs seem to be linked to cardiomyopathy and myocarditis. The study shows the potential of bayesian neural networks in analysing data on drug safety.

SUBMITTER: Coulter DM 

PROVIDER: S-EPMC31617 | biostudies-literature | 2001 May

REPOSITORIES: biostudies-literature

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Antipsychotic drugs and heart muscle disorder in international pharmacovigilance: data mining study.

Coulter D M DM   Bate A A   Meyboom R H RH   Lindquist M M   Edwards I R IR  

BMJ (Clinical research ed.) 20010501 7296


<h4>Objectives</h4>To examine the relation between antipsychotic drugs and myocarditis and cardiomyopathy.<h4>Design</h4>Data mining using bayesian statistics implemented in a neural network architecture.<h4>Setting</h4>International database on adverse drug reactions run by the World Health Organization programme for international drug monitoring.<h4>Main outcome measures</h4>Reports mentioning antipsychotic drugs, cardiomyopathy, or myocarditis.<h4>Results</h4>A strong signal existed for an as  ...[more]

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