Interleukin-2 is present in human blood vessels and released in biologically active form by heparanase.
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ABSTRACT:
SUBMITTER: Miller JD
PROVIDER: S-EPMC3162067 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
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Interleukin-2 is present in human blood vessels and released in biologically active form by heparanase.
Miller John D JD Clabaugh Suzanne E SE Smith Deandra R DR Stevens R Brian RB Wrenshall Lucile E LE
Immunology and cell biology 20110524 2
Interleukin-2 (IL-2) is a multifaceted cytokine with immunostimulatory and immunosuppressive properties. Our laboratory recently demonstrated that the availability of IL-2 is regulated, in part, by association with perlecan, a heparan sulfate proteoglycan. Given the abundance of perlecan in blood vessels, we asked whether IL-2 is present in vessel walls. Our results indicate that IL-2 is associated with endothelial and smooth muscle cells within the human arterial wall. This IL-2 is released by ...[more]
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