Differential regulation of polysome mRNA levels in mouse Hepa-1C1C7 cells exposed to dioxin.
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ABSTRACT:
SUBMITTER: Thornley JA
PROVIDER: S-EPMC3162130 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Publications
Differential regulation of polysome mRNA levels in mouse Hepa-1C1C7 cells exposed to dioxin.
Thornley Jessica A JA Trask Heidi W HW Ridley Christian J A CJ Korc Murray M Gui Jiang J Ringelberg Carol S CS Wang Sinny S Tomlinson Craig R CR
Toxicology in vitro : an international journal published in association with BIBRA 20110504 7
The environmental agent 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin) causes a multitude of human illnesses. In order to more fully understand the underlying biology of TCDD toxicity, we tested the hypothesis that new candidate genes could be identified using polysome RNA from TCDD-treated mouse Hepa-1c1c7 cells. We found that (i) differentially expressed whole cell and cytoplasm RNA levels are both poor predictors of polysome RNA levels; (ii) for a majority of RNAs, differential RNA leve ...[more]
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