Ontology highlight
ABSTRACT:
SUBMITTER: Jiang C
PROVIDER: S-EPMC3162137 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Jiang Caifu C Mithani Aziz A Gan Xiangchao X Belfield Eric J EJ Klingler John P JP Zhu Jian-Kang JK Ragoussis Jiannis J Mott Richard R Harberd Nicholas P NP
Current biology : CB 20110728 16
Multicellular organisms can be regenerated from totipotent differentiated somatic cell or nuclear founders [1-3]. Organisms regenerated from clonally related isogenic founders might a priori have been expected to be phenotypically invariant. However, clonal regenerant animals display variant phenotypes caused by defective epigenetic reprogramming of gene expression [2], and clonal regenerant plants exhibit poorly understood heritable phenotypic ("somaclonal") variation [4-7]. Here we show that s ...[more]