Ontology highlight
ABSTRACT:
SUBMITTER: Wu CY
PROVIDER: S-EPMC3162441 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Wu Ching-Yuan CY Kang Hong-Yo HY Yang Wei-Lei WL Wu Juan J Jeong Yun Seong YS Wang Jing J Chan Chia-Hsin CH Lee Szu-Wei SW Zhang Xian X Lamothe Betty B Campos Alejandro D AD Darnay Bryant G BG Lin Hui-Kuan HK
The Journal of biological chemistry 20110620 35
DNA damage response is an important surveillance mechanism used to maintain the integrity of the human genome in response to genotoxic stress. Histone variant H2AX is a critical sensor that undergoes phosphorylation at serine 139 upon genotoxic stress, which provides a docking site to recruit the mediator of DNA damage checkpoint protein 1 (MDC1) and DNA repair protein complex to sites of DNA breaks for DNA repair. Here, we show that monoubiquitination of H2AX is induced upon DNA double strand b ...[more]