Ontology highlight
ABSTRACT:
SUBMITTER: Agrawal N
PROVIDER: S-EPMC3162986 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20110728 6046
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. To explore the genetic origins of this cancer, we used whole-exome sequencing and gene copy number analyses to study 32 primary tumors. Tumors from patients with a history of tobacco use had more mutations than did tumors from patients who did not use tobacco, and tumors that were negative for human papillomavirus (HPV) had more mutations than did HPV-positive tumors. Six of the genes that were mutated in mu ...[more]