Ontology highlight
ABSTRACT:
SUBMITTER: Igyarto BZ
PROVIDER: S-EPMC3163010 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Igyártó Botond Z BZ Haley Krystal K Ortner Daniela D Bobr Aleh A Gerami-Nejad Maryam M Edelson Brian T BT Zurawski Sandra M SM Malissen Bernard B Zurawski Gerard G Berman Judith J Kaplan Daniel H DH
Immunity 20110721 2
Skin-resident dendritic cells (DCs) are well positioned to encounter cutaneous pathogens and are required for the initiation of adaptive immune responses. There are at least three subsets of skin DC- Langerhans cells (LC), Langerin(+) dermal DCs (dDCs), and classic dDCs. Whether these subsets have distinct or redundant function in vivo is poorly understood. Using a Candida albicans skin infection model, we have shown that direct presentation of antigen by LC is necessary and sufficient for the g ...[more]