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Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses.


ABSTRACT: Skin-resident dendritic cells (DCs) are well positioned to encounter cutaneous pathogens and are required for the initiation of adaptive immune responses. There are at least three subsets of skin DC- Langerhans cells (LC), Langerin(+) dermal DCs (dDCs), and classic dDCs. Whether these subsets have distinct or redundant function in vivo is poorly understood. Using a Candida albicans skin infection model, we have shown that direct presentation of antigen by LC is necessary and sufficient for the generation of antigen-specific T helper-17 (Th17) cells but not for the generation of cytotoxic lymphocytes (CTLs). In contrast, Langerin(+) dDCs are required for the generation of antigen specific CTL and Th1 cells. Langerin(+) dDCs also inhibited the ability of LCs and classic DCs to promote Th17 cell responses. This work demonstrates that skin-resident DC subsets promote distinct and opposing antigen-specific responses.

SUBMITTER: Igyarto BZ 

PROVIDER: S-EPMC3163010 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

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Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses.

Igyártó Botond Z BZ   Haley Krystal K   Ortner Daniela D   Bobr Aleh A   Gerami-Nejad Maryam M   Edelson Brian T BT   Zurawski Sandra M SM   Malissen Bernard B   Zurawski Gerard G   Berman Judith J   Kaplan Daniel H DH  

Immunity 20110721 2


Skin-resident dendritic cells (DCs) are well positioned to encounter cutaneous pathogens and are required for the initiation of adaptive immune responses. There are at least three subsets of skin DC- Langerhans cells (LC), Langerin(+) dermal DCs (dDCs), and classic dDCs. Whether these subsets have distinct or redundant function in vivo is poorly understood. Using a Candida albicans skin infection model, we have shown that direct presentation of antigen by LC is necessary and sufficient for the g  ...[more]

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