Ontology highlight
ABSTRACT:
SUBMITTER: Song JJ
PROVIDER: S-EPMC3163960 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Song Jason J JJ Hwang Inyong I Cho Kyung H KH Garcia Michael A MA Kim Arthur J AJ Wang Tiffany H TH Lindstrom Tamsin M TM Lee Annette T AT Nishimura Toshihiko T Zhao Lei L Morser John J Nesheim Michael M Goodman Stuart B SB Lee David M DM Bridges S Louis SL Gregersen Peter K PK Leung Lawrence L LL Robinson William H WH
The Journal of clinical investigation 20110801 9
The immune and coagulation systems are both implicated in the pathogenesis of rheumatoid arthritis (RA). Plasma carboxypeptidase B (CPB), which is activated by the thrombin/thrombomodulin complex, plays a procoagulant role during fibrin clot formation. However, an antiinflammatory role for CPB is suggested by the recent observation that CPB can cleave proinflammatory mediators, such as C5a, bradykinin, and osteopontin. Here, we show that CPB plays a central role in downregulating C5a-mediated in ...[more]