Ontology highlight
ABSTRACT:
SUBMITTER: Lagrange T
PROVIDER: S-EPMC316406 | biostudies-literature | 1998 Jan
REPOSITORIES: biostudies-literature
Lagrange T T Kapanidis A N AN Tang H H Reinberg D D Ebright R H RH
Genes & development 19980101 1
A sequence element located immediately upstream of the TATA element, and having the consensus sequence 5'-G/C-G/C-G/A-C-G-C-C-3', affects the ability of transcription factor IIB to enter transcription complexes and support transcription initiation. The sequence element is recognized directly by the transcription factor IIB. Recognition involves alpha-helices 4' and 5' of IIB, which comprise a helix-turn-helix DNA-binding motif. These observations establish that transcription initiation involves ...[more]