Ontology highlight
ABSTRACT:
SUBMITTER: Hoque M
PROVIDER: S-EPMC3164259 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Hoque Mainul M Shamanna Raghavendra A RA Guan Deyu D Pe'ery Tsafi T Mathews Michael B MB
Journal of molecular biology 20110701 5
Human immunodeficiency virus (HIV) exploits cellular proteins during its replicative cycle and latent infection. The positive transcription elongation factor b (P-TEFb) is a key cellular transcription factor critical for these viral processes and is a drug target. During viral replication, P-TEFb is recruited via interactions of its cyclin T1 subunit with the HIV Tat (transactivator of transcription) protein and TAR (transactivation response) element. Through RNA silencing and over-expression ex ...[more]