Ontology highlight
ABSTRACT:
SUBMITTER: Cheong PH
PROVIDER: S-EPMC3164362 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Cheong Paul Ha-Yeon PH Yun Heedong H Danishefsky Samuel J SJ Houk K N KN
Organic letters 20060401 8
[reaction: see text] The stereoselectivity of the key epoxidation step in the synthesis of guanacastepene A is shown to be controlled by torsional steering. In this particular epoxidation reaction, the transition structure energetic difference is enhanced by the great asynchronicity of the forming C-O bonds that intensifies the torsional interactions. ...[more]