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Multicomponent assembly strategies for the synthesis of diverse tetrahydroisoquinoline scaffolds.

ABSTRACT: Several novel multicomponent assembly processes have been developed for the rapid and efficient assembly of various heterocyclic scaffolds bearing a tetrahydroisoquinoline core, each of which allows for facile derivatization to access a diverse array of compounds. This work led to the serendipitous discovery of a new method for the synthesis of a fused quinazolone ring system, which was applied to a one-step total synthesis of the quinazolinocarboline alkaloid rutaecarpine.

SUBMITTER: Granger BA

PROVIDER: S-EPMC3164803 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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Multicomponent assembly strategies for the synthesis of diverse tetrahydroisoquinoline scaffolds.

Granger Brett A BA Kaneda Kyosuke K Martin Stephen F SF

Organic letters 20110811 17

Several novel multicomponent assembly processes have been developed for the rapid and efficient assembly of various heterocyclic scaffolds bearing a tetrahydroisoquinoline core, each of which allows for facile derivatization to access a diverse array of compounds. This work led to the serendipitous discovery of a new method for the synthesis of a fused quinazolone ring system, which was applied to a one-step total synthesis of the quinazolinocarboline alkaloid rutaecarpine. ...[more]

PMID: 21834504

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