Ontology highlight
ABSTRACT:
SUBMITTER: Marrack P
PROVIDER: S-EPMC3164820 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Annual review of immunology 20080101
The rules for the conserved reaction of alphabeta T cell receptors (TCRs) with major histocompatibility complex (MHC) proteins plus peptides are poorly understood, probably because thymocytes bearing TCRs with the strongest MHC reactivity are lost by negative selection. Thus, only TCRs with an attenuated ability to react with MHC appear on mature T cells. Also, the interaction sites between TCRs and MHC may be inherently flexible and hence difficult to spot. We reevaluated contacts between TCRs ...[more]