Ontology highlight
ABSTRACT:
SUBMITTER: Shelly M
PROVIDER: S-EPMC3164872 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Shelly Maya M Cancedda Laura L Lim Byung Kook BK Popescu Andrei T AT Cheng Pei-lin PL Gao Hongfeng H Poo Mu-ming MM
Neuron 20110801 3
Semaphorin 3A (Sema3A) is a secreted factor known to guide axon/dendrite growth and neuronal migration. We found that it also acts as a polarizing factor for axon/dendrite development in cultured hippocampal neurons. Exposure of the undifferentiated neurite to localized Sema3A suppressed its differentiation into axon and promoted dendrite formation, resulting in axon formation away from the Sema3A source, and bath application of Sema3A to polarized neurons promoted dendrite growth but suppressed ...[more]