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Presenilin 1 regulates homeostatic synaptic scaling through Akt signaling.

ABSTRACT: Neurons adapt to long-lasting changes in network activity, both in vivo and in vitro, by adjusting their synaptic strengths to stabilize firing rates. We found that homeostatic scaling of excitatory synapses was impaired in hippocampal neurons derived from mice lacking presenilin 1 (Psen1(-/-) mice) or expressing a familial Alzheimer's disease-linked Psen1 mutation (Psen1(M146V)). These findings suggest that deficits in synaptic homeostasis may contribute to brain dysfunction in Alzheimer's disease.

SUBMITTER: Pratt KG

PROVIDER: S-EPMC3164917 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

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Presenilin 1 regulates homeostatic synaptic scaling through Akt signaling.

Pratt Kara G KG Zimmerman Eric C EC Cook David G DG Sullivan Jane M JM

Nature neuroscience 20110814 9

Neurons adapt to long-lasting changes in network activity, both in vivo and in vitro, by adjusting their synaptic strengths to stabilize firing rates. We found that homeostatic scaling of excitatory synapses was impaired in hippocampal neurons derived from mice lacking presenilin 1 (Psen1(-/-) mice) or expressing a familial Alzheimer's disease-linked Psen1 mutation (Psen1(M146V)). These findings suggest that deficits in synaptic homeostasis may contribute to brain dysfunction in Alzheimer's dise ...[more]

PMID: 21841774

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