Fast-spiking interneurons have an initial orientation bias that is lost with vision.
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ABSTRACT:
SUBMITTER: Kuhlman SJ
PROVIDER: S-EPMC3164933 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Publications
Fast-spiking interneurons have an initial orientation bias that is lost with vision.
Kuhlman Sandra J SJ Tring Elaine E Trachtenberg Joshua T JT
Nature neuroscience 20110712 9
We found that in mice, following eye opening, fast-spiking, parvalbumin-positive GABAergic interneurons had well-defined orientation tuning preferences and that subsequent visual experience broadened this tuning. Broad inhibitory tuning was not required for the developmental sharpening of excitatory tuning but did precede binocular matching of excitatory orientation tuning. We propose that experience-dependent broadening of inhibition is a candidate for initiating the critical period of excitato ...[more]
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