Ontology highlight
ABSTRACT:
SUBMITTER: de Vries SS
PROVIDER: S-EPMC316502 | biostudies-literature | 1999 Mar
REPOSITORIES: biostudies-literature
de Vries S S SS Baart E B EB Dekker M M Siezen A A de Rooij D G DG de Boer P P te Riele H H
Genes & development 19990301 5
Members of the mammalian mismatch repair protein family of MutS and MutL homologs have been implicated in postreplicative mismatch correction and chromosome interactions during meiotic recombination. Here we demonstrate that mice carrying a disruption in MutS homolog Msh5 show a meiotic defect, leading to male and female sterility. Histological and cytological examination of prophase I stages in both sexes revealed an extended zygotene stage, characterized by impaired and aberrant chromosome syn ...[more]