Ontology highlight
ABSTRACT:
SUBMITTER: Hengzhuang W
PROVIDER: S-EPMC3165294 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Hengzhuang Wang W Wu Hong H Ciofu Oana O Song Zhijun Z Høiby Niels N
Antimicrobial agents and chemotherapy 20110613 9
The time course of activity of colistin and imipenem against mucoid and nonmucoid Pseudomonas aeruginosa growing in a biofilm showed that compared with those for planktonic bacteria, the kinetics of colistin and imipenem retained the concentration- and time-dependent killing, respectively, but higher doses of antibiotics and longer dosing periods were required for biofilm eradication. Biofilms of mucoid P. aeruginosa were more difficult to eradicate than nonmucoid biofilms. ...[more]