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Molecular characterization of a catalase-negative Staphylococcus aureus subsp. aureus Strain collected from a patient with mitral valve endocarditis and pericarditis revealed a novel nonsense mutation in the katA gene.

ABSTRACT: We report a case of endocarditis and pericarditis caused by catalase-negative Staphylococcus aureus. Molecular characterization revealed a novel nonsense mutation in the katA gene, leading to a loss of 238 amino acids (47% of the wild-type catalase protein), including the heme-binding site, NADPH-binding region, and Tyr-337, essential for catalysis.

SUBMITTER: To KK

PROVIDER: S-EPMC3165592 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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Molecular characterization of a catalase-negative Staphylococcus aureus subsp. aureus Strain collected from a patient with mitral valve endocarditis and pericarditis revealed a novel nonsense mutation in the katA gene.

To Kelvin K W KK Cheng Vincent C C VC Chan Jasper F W JF Wong Amy C Y AC Chau Sandy S Tsang Flora H F FH Curreem Shirly O T SO Lau Susanna K P SK Yuen Kwok-Yung KY Woo Patrick C Y PC

Journal of clinical microbiology 20110629 9

We report a case of endocarditis and pericarditis caused by catalase-negative Staphylococcus aureus. Molecular characterization revealed a novel nonsense mutation in the katA gene, leading to a loss of 238 amino acids (47% of the wild-type catalase protein), including the heme-binding site, NADPH-binding region, and Tyr-337, essential for catalysis. ...[more]

PMID: 21715584

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