A molecular basis for tungstate selectivity in prokaryotic ABC transport systems.
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ABSTRACT:
SUBMITTER: Bevers LE
PROVIDER: S-EPMC3165707 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Publications
A molecular basis for tungstate selectivity in prokaryotic ABC transport systems.
Bevers Loes E LE Schwarz Guenter G Hagen Wilfred R WR
Journal of bacteriology 20110722 18
The essential trace compounds tungstate and molybdate are taken up by cells via ABC transporters. Despite their similar ionic radii and chemical properties, the WtpA protein selectively binds tungstate in the presence of molybdate. Using site-directed mutagenesis of conserved binding pocket residues, we established a molecular basis for tungstate selectivity. ...[more]
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