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RosettaRemodel: a generalized framework for flexible backbone protein design.

ABSTRACT: We describe RosettaRemodel, a generalized framework for flexible protein design that provides a versatile and convenient interface to the Rosetta modeling suite. RosettaRemodel employs a unified interface, called a blueprint, which allows detailed control over many aspects of flexible backbone protein design calculations. RosettaRemodel allows the construction and elaboration of customized protocols for a wide range of design problems ranging from loop insertion and deletion, disulfide engineering, domain assembly, loop remodeling, motif grafting, symmetrical units, to de novo structure modeling.

SUBMITTER: Huang PS

PROVIDER: S-EPMC3166072 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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RosettaRemodel: a generalized framework for flexible backbone protein design.

Huang Po-Ssu PS Ban Yih-En Andrew YE Richter Florian F Andre Ingemar I Vernon Robert R Schief William R WR Baker David D

PloS one 20110831 8

We describe RosettaRemodel, a generalized framework for flexible protein design that provides a versatile and convenient interface to the Rosetta modeling suite. RosettaRemodel employs a unified interface, called a blueprint, which allows detailed control over many aspects of flexible backbone protein design calculations. RosettaRemodel allows the construction and elaboration of customized protocols for a wide range of design problems ranging from loop insertion and deletion, disulfide engineeri ...[more]

PMID: 21909381

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