Ontology highlight
ABSTRACT:
SUBMITTER: Matsushita N
PROVIDER: S-EPMC3166142 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Matsushita Nobuko N Endo Yujiro Y Sato Koichi K Kurumizaka Hitoshi H Yamashita Takayuki T Takata Minoru M Yanagi Shigeru S
PloS one 20110831 8
Fanconi anemia (FA), an inherited disease, is associated with progressive bone marrow failure, predisposition to cancer, and genomic instability. Genes corresponding to 15 identified FA complementation groups have been cloned, and each gene product functions in the response to DNA damage induced by cross-linking agents and/or in protection against genome instability. Interestingly, overproduction of inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) and aberrant activation of NF- ...[more]