Ontology highlight
ABSTRACT:
SUBMITTER: Wang D
PROVIDER: S-EPMC3166341 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Wang Da D Hurst Tamiika K TK Thompson Richard B RB Fierke Carol A CA
Journal of biomedical optics 20110801 8
Zinc is an essential element for numerous cellular processes, therefore zinc homeostasis is regulated in living organisms. Fluorescent sensors have been developed as important tools to monitor the concentrations of readily exchangeable zinc in live cells. One type of biosensor uses carbonic anhydrase (CA) as the recognition element based on its tunable affinity, superior metal selectivity, and fluorescence signal from aryl sulfonamide ligands coupled to zinc binding. Here, we fuse carbonic anhyd ...[more]