Ontology highlight
ABSTRACT:
SUBMITTER: Matsumoto S
PROVIDER: S-EPMC3166479 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Cell cycle (Georgetown, Tex.) 20101201 23
In fission yeast, replication fork arrest activates the replication checkpoint effector kinase Cds1(Chk2/Rad53) through the Rad3(ATR/Mec1)-Mrc1(Claspin) pathway. Hsk1, the Cdc7 homologue of fission yeast required for efficient initiation of DNA replication, is also required for Cds1 activation. Hsk1 kinase activity is required for induction and maintenance of Mrc1 hyperphosphorylation, which is induced by replication fork block and mediated by Rad3. Rad3 kinase activity does not change in an hsk ...[more]