Ontology highlight
ABSTRACT:
SUBMITTER: Rutkoski TJ
PROVIDER: S-EPMC3166498 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Rutkoski Thomas J TJ Kink John A JA Strong Laura E LE Raines Ronald T RT
Cancer biology & therapy 20110801 3
Mammalian ribonucleases are emerging as cancer chemotherapeutic agents. Their cationicity engenders cell permeability, and their enzymatic activity destroys the biochemical information encoded by RNA. The pharmacologic potential of ribonucleases is, however, obviated by their high sensitivity to a cytosolic inhibitor protein (RI) and their small size, which limits their residence in serum. We reasoned that site specific conjugation of a poly(ethylene glycol) (PEG) chain could both reduce sensiti ...[more]